Flow Imaging Microscopy (FIM) via FlowCam plays a crucial role in biotherapeutic development by providing a tool for quantifying and characterizing particles. The body of scientific research using FlowCam technology to analyze biotherapeutic samples is continuing to grow and expand. Some of these applications include characterizing protein aggregates, supporting in-use studies, monitoring degradation products, evaluating subvisible particles, optimizing instrument settings, and assessing cell viability.
The publications identified in this summary demonstrate several key aspects of FlowCam's utility in biotherapeutic development:
Versatility in Applications: FlowCam is used across a variety of applications, including protein, cell, and gene therapies, showcasing its adaptability in different areas of biotherapeutic research.
Accurate Particle Characterization: FlowCam effectively characterizes and quantifies particles, such as protein aggregates, free fatty acid particles from polysorbate degradation, and subvisible particles in lipid nanoparticles, which are crucial for ensuring the quality and safety of biotherapeutics.
Support for In-Use Studies: FlowCam helps evaluate the impact of clinical handling on the stability of therapies, such as the effect of syringe handling on protein aggregation. This provides valuable insights for improving drug administration practices.
Optimization of Measurement Techniques: FlowCam helps optimize instrument settings for precise particle measurements, even for small particles like those in adeno-associated virus (AAV) therapies, ensuring consistent and accurate data.
Efficient Cell Viability Assessment: It offers a more efficient method for assessing cell viability compared to traditional techniques, which is essential for developing effective cell therapies.
Innovation in Particle Standards: FlowCam is instrumental in validating innovative particle standards, such as those produced by 3D printing technology, which simulate protein aggregates for better quality control.
The cited publications on this list underscore the significance of FlowCam as a vital instrument for particle characterization and highlight its potential to inspire novel applications within biotherapeutic research.
We continually examine the academic literature where FlowCam is employed in essential and pioneering studies in this domain and strive to promote the research among our readership. To see a comprehensive list of FlowCam citations in published research, visit our FlowCam Bibliography.
